Sezvo ganda zera, kune kuderera kwe physiologic basa. Shanduko idzi dzinokonzerwa nezvose zviri mukati (chronologic) uye extrinsic (zvikurukuru UV-induced) zvinhu. Botanicals inopa mabhenefiti anogona kurwisa zvimwe zvezviratidzo zvekuchembera. Pano, isu tinoongorora sarudza botanicals uye humbowo hwesainzi kuseri kwezvirevo zvavo zvekurwisa kuchembera. Botanicals inogona kupa anti-kuzvimba, antioxidant, moisturizing, UV-inodzivirira, uye zvimwe zvinokonzeresa. Huwandu hwe botanicals hwakanyorwa sezvimiro mune zvakakurumbira cosmetics uye cosmeceuticals, asi mashoma akasarudzwa anokurukurwa pano. Izvi zvakasarudzwa zvichibva pakuwanikwa kwedata resainzi, kufarira kwevanyori, uye "kukurumbira" kunoonekwa kwezvinogadzirwa zvecosmetic uye cosmeceutical. Iwo botanical akaongororwa pano anosanganisira argan mafuta, kokonati mafuta, crocin, feverfew, green tea, marigold, pomegranate, uye soya.
Keywords: botanical; anti-kuchembera; argan mafuta; kokonati mafuta; crocin; feverfew; green tea; marigold; pomegraneti; soy
3.1. Argan Mafuta
3.1.1. Nhoroondo, Kushandiswa, uye Zvikumbiro
Mafuta eArgan anowanikwa kuMorocco uye anogadzirwa kubva kumbeu yeArgania sponosa L. Iine zvakawanda zvechivanhu zvinoshandiswa zvakadai sekubika, kurapa zvirwere zveganda, uye kuchengetedza ganda nebvudzi.
3.1.2. Kuumbwa uye Mechanism Yekuita
Oiri yeArgan inoumbwa ne80% monounsaturated mafuta uye 20% saturated fatty acids uye ine polyphenols, tocopherols, sterols, squalene, uye triterpene doro.
3.1.3. Uchapupu hweSainzi
Oiri yeArgan yagara ichishandiswa muMorocco kuderedza kupenya kwemavara kumeso, asi hwaro hwesainzi hwechido ichi hwakanga husinganzwisisike. Muchidzidzo chegonzo, argan mafuta inhibited tyrosinase uye dopachrome tautomerase kutaura muB16 murine melanoma masero, zvichikonzera kuderera-kunoenderana nedosi mune melanin yemukati. Izvi zvinoratidza kuti mafuta eargan anogona kunge ari inhibitor ine simba ye melanin biosynthesis, asi randomized control miedzo (RTC) muzvidzidzo zvevanhu inodiwa kuti vaone iyi hypothesis.
RTC diki yevakadzi makumi matanhatu mushure memenopausal yakaratidza kuti kushandiswa kwemazuva ese uye / kana topical kushandiswa kweargan mafuta kwakaderedza transepidermal kurasikirwa kwemvura (TEWL), yakagadziridzwa elasticity yeganda, zvichienderana nekuwedzera kweR2 (gross elasticity yeganda), R5. (net elasticity yeganda), uye R7 (biological elasticity) parameters uye kuderera kweresonance running time (RRT) (chiyero chinopesana neganda. elasticity). Mapoka acho akaverengerwa kuti adye mafuta emuorivhi kana argan mafuta. Mapoka ese ari maviri akaisa mafuta eargan kuruboshwe volar wrist chete. Zviyero zvakatorwa kubva kurudyi uye kuruboshwe volar wrists. Kuvandudzwa kwekusagadzikana kwakaonekwa mumapoka ose ari pachiwoko apo mafuta eargan aishandiswa pamusoro, asi pachiwoko apo mafuta eargan haana kushandiswa chete boka raidya mafuta argan raive nekuwedzera kukuru mukusimba [31]. Izvi zvakakonzerwa nekuwedzera kwe antioxidant yemukati mumafuta argan kana ichienzaniswa nemafuta omuorivhi. Zvinofungidzirwa kuti izvi zvinogona kunge zviri nekuda kweiyo Vitamin E uye ferulic acid yemukati, iyo inozivikanwa antioxidants.
3.2. Kokonati Mafuta
3.2.1. Nhoroondo, Kushandiswa, uye Zvikumbiro
Kokonati mafuta inotorwa kubva kumuchero wakaomeswa weCocos nucifera uye ine zvakawanda zvinoshandiswa, zvese zvekare uye zvemazuva ano. Yakashandiswa sechinhu chinonhuwira, ganda, uye bvudzi conditioning agent, uye mune zvakawanda zvigadzirwa zvekuzora. Nepo mafuta ekokonati aine akawanda anobva kunze, anosanganisira kokonati asidhi, hydrogenated coconut acid, uye hydrogenated kokonati mafuta, isu tichakurukura tsvakiridzo yezvichemo zvine chekuita nevirgin kokonati mafuta (VCO), iyo inogadzirwa pasina kupisa.
Kokonati mafuta yakashandiswa pakunyorovesa kweganda remucheche uye inogona kubatsira mukurapa kweatopic dermatitis kune ese ayo anonyorovesa maitiro uye ayo anogona kuitika paStaphylococcus aureus uye mamwe hutachiona hweganda mune atopic varwere. Mafuta eCoconut akaratidzwa kuderedza S. aureus colonization paganda revakuru vane atopic dermatitis mune kaviri-bofu RTC.
3.2.2. Kuumbwa uye Mechanism Yekuita
Kokonati mafuta inoumbwa ne90-95% saturated triglycerides (lauric acid, myristic acid, caprylic acid, capric acid, uye palmitic acid). Izvi zvinopesana nemafuta mazhinji emiriwo / emichero, ayo anonyanya kuumbwa nemafuta asina unsaturated. Musoro wepamusoro wakaiswa saturated triglycerides inoshanda kunyorovesa ganda senge emollient nekudzikamisa mipendero yakaoma yakamonereka ye corneocytes uye kuzadza mikaha pakati pawo.
3.2.3. Uchapupu hweSainzi
Kokonati mafuta anogona kunyorovesa yakaoma kuchembera ganda. Makumi matanhatu nemaviri muzana emafuta acids muVCO akareba zvakafanana uye 92% akazara, izvo zvinobvumira kusimba kurongedza izvo zvinoguma mune yakakura occlusive mhedzisiro kupfuura mafuta omuorivhi. Iyo triglycerides mukokonati mafuta inoputswa ne lipases muyakajairika ganda flora kusvika glycerin uye fatty acids. Glycerin iine humectant ine simba, iyo inokwezva mvura kune corneal layer ye epidermis kubva kune kunze kwezvakatipoteredza uye yakadzika ganda. Iwo mafuta acids muVCO ane low linoleic acid content, iyo yakakosha sezvo linoleic acid inogona kutsamwisa ganda. Kokonati mafuta yakakwirira kune mineral oil mukuderedza TEWL muvarwere vane atopic dermatitis uye inoshanda uye yakachengeteka semineral oil mukurapa xerosis.
Lauric acid, inotangira monolaurin uye chikamu chinokosha cheVCO, inogona kuva ne-anti-inflammatory properties, inokwanisa kugadzirisa kupararira kwemasero ekudzivirira uye kuva nemhosva kune mamwe emishonga inorwisa mabhakitiriya yeVCO. VCO ine yakakwirira yeferulic acid uye p-coumaric acid (zvose phenolic acids), uye mazinga akakwirira eaya phenolic acids anobatanidzwa nekuwedzera kwe antioxidant simba. Phenolic acids inoshanda pakurwisa UV-induced kukuvara. Nekudaro, kunyangwe zvichitaurwa kuti kokonati oiri inogona kushanda sezuva, in vitro zvidzidzo zvinoratidza kuti inopa zvishoma-ku-hapana UV-kuvharira mukana.
Pamusoro pekunyorovesa uye antioxidant mhedzisiro, mhando dzemhuka dzinoratidza kuti VCO inogona kuderedza maronda ekuporesa nguva. Paiva nehuwandu hwekuwedzera kwepepsin-soluble collagen (yakakwirira collagen cross-linking) muVCO-yakarapwa maronda kana ichienzaniswa nekutonga. Histopathology yakaratidza kuwedzera fibroblast kuwedzera uye neovascularization mumaronda aya. Zvimwe zvidzidzo zvinodiwa kuti uone kana topical application yeVCO inogona kuwedzera collagen mazinga mukuchembera ganda remunhu.
3.3. Crocin
3.3.1. Nhoroondo, Kushandiswa, Zvikumbiro
Crocin is biologically active component yesafuroni, yakabva pakuomeswa kwakashata kweCrocus sativus L. Saffron inorimwa munyika dzakawanda dzinosanganisira Iran, India, neGreece, uye yakashandiswa mumishonga yechivanhu kuderedza zvirwere zvakasiyana-siyana zvinosanganisira kuora mwoyo, kuzvimba. , chirwere chechiropa, nezvimwe zvakawanda.
3.3.2. Kuumbwa uye Mechanism Yekuita
Crocin inokonzera ruvara rwesafoni. Crocin inowanikwawo mumuchero we Gardenia jasminoides Ellis. Inotsanangurwa se carotenoid glycoside.
3.3.3. Uchapupu hweSainzi
Crocin ine antioxidant mhedzisiro, inodzivirira squalene kubva kune UV-induced peroxidation, uye inodzivirira kuburitswa kweanopisa vapomeri. The antioxidant effect yakaratidzwa mu in vitro assays yakaratidza hukuru hwe antioxidant basa kana ichienzaniswa neVitamin C. Uyezve, crocin inhibits UVA-induced cell membrane peroxidation uye inodzivisa kutaura kwevakawanda vanopikisa pro-inflammatory mediators kusanganisira IL-8, PGE-2, IL. -6, TNF-α, IL-1α, uye LTB4. Iyo inoderedzawo kutaura kweakawanda NF-κB anotsamira majini. Muchidzidzo chichishandisa mafibroblasts ane tsika dzevanhu, crocin yakaderedza UV-induced ROS, yakasimudzira kutaura kweextracellular matrix protein Col-1, uye yakaderedza huwandu hwemasero ane senescent phenotypes mushure me UV radiation. Inoderedza kugadzirwa kweROS uye inomisa apoptosis. Crocin yakaratidzwa kudzvinyirira ERK/MAPK/NF-κB/STAT nzira dzechiratidzo mumasero eHaCaT mu vitro. Kunyangwe crocin ine mukana senge anti-kuchembera cosmeceutical, iyo komisheni ine labile. Iko kushandiswa kwenanostructured lipid dispersions kune topical management yakaongororwa nemhedzisiro inovimbisa. Kuti uone mhedzisiro yecrocin mu vivo, mamwe mhando dzemhuka uye randomized kiriniki miedzo inodiwa.
3.4. Feverfew
3.4.1. Nhoroondo, Kushandiswa, Zvikumbiro
Feverfew, Tanacetum parthenium, muriwo usingaperi wakashandiswa kune zvakawanda zvinangwa mumishonga yechivanhu.
3.4.2. Kuumbwa uye Mechanism Yekuita
Feverfew ine parthenolide, sesquiterpene lactone, iyo inogona kunge iine mutoro kune mamwe maitiro ayo anopesana nekuputika, kuburikidza nekudzivisa kweNF-κB. Uku kudziviswa kweNF-κB kunoratidzika kunge kwakasununguka kune parthenolide's antioxidant effects. Parthenolide yakaratidzawo anticancer mhedzisiro inopesana neUVB-induced cancer cancer uye ne melanoma masero in vitro. Sezvineiwo, parthenolide inogonawo kukonzera allergic reaction, oral blisters, uye allergic contact dermatitis. Nekuda kwekunetseka uku, ikozvino inowanzobviswa feverfew isati yawedzerwa kune zvigadzirwa zvekuzora.
3.4.3. Uchapupu hweSainzi
Nekuda kwematambudziko anogona kuitika nekushandiswa kwepamusoro kweparthenolide, zvimwe zvinogadzirwa zvekuzora zvine feverfew zvinoshandisa parthenolide-depleted feverfew (PD-feverfew), iyo inoti haina simba rekukurudzira. PD-feverfew inogona kuwedzera endogenous DNA-kugadzirisa basa muganda, zvinogona kuderedza UV-induced DNA kukuvara. Muchidzidzo che in vitro, PD-feverfew yakadzikira UV-induced hydrogen peroxide kuumbwa uye yakadzikira kuburitswa kwepro-inflammatory cytokine. Yakaratidza yakasimba antioxidant mhedzisiro kupfuura muenzanisi, Vitamin C, uye yakadzikira UV-induced erythema mune 12-chidzidzo RTC.
3.5. Green Tea
3.5.1. Nhoroondo, Kushandiswa, Zvikumbiro
Green tea yakadyiwa nekuda kwehutano hwayo muChina kwemazana emakore. Nekuda kweiyo ine simba antioxidant mhedzisiro, kune kufarira mukuvandudzwa kweyakagadzikana, bioavailable topical formulation.
3.5.2. Kuumbwa uye Mechanism Yekuita
Tii yegirini, kubva kuCamellia sinensis, ine akawanda bioactive komisheni ine zvinogoneka zvekurwisa kuchembera, kusanganisira caffeine, mavhitaminzi, uye polyphenols. Mapolyphenols makuru mugirini tii makatechini, kunyanya gallocatechin, epigallocatechin (ECG), uye epigallocatechin-3-gallate (EGCG). Epigallocatechin-3-gallate ine antioxidant, photoprotective, immunomodulatory, anti-angiogenic, uye anti-inflammatory properties. Green tii zvakare ine yakakwira yakawanda yeflavonol glycoside kaempferol, iyo inonyatso kunyura muganda mushure mekushandisa topical.
3.5.3. Uchapupu hweSainzi
Green tea inobvisa inoderedza intracellular ROS kugadzirwa mu vitro uye yakaderedza ROS-induced necrosis. Epigallocatechin-3-gallate (a green tea polyphenol) inhibisa UV-induced kusunungurwa kwehydrogen peroxide, inodzvinyirira phosphorylation yeMAPK, uye inoderedza kuzvimba kuburikidza nekushandiswa kweNF-κB. Uchishandisa ganda re ex vivo kubva kumukadzi ane hutano ane makore makumi matatu nerimwe, ganda rakagadzirwa nechena kana girinhi tii yakatorwa yakaratidza kuchengetwa kwemasero eLangerhans (maseru anoburitsa antigen ane chekuita nekupinzwa kwekudzivirira muganda) mushure mekuvhenekwa kweUV.
Mune modhi yembeva, kushandiswa kwepamusoro kwegirinhi tii inotorwa isati yaratidzwa UV yakakonzera kudzikira erythema, kuderera kweganda kupinza kweleukocytes, uye kuderera kwemyeloperoxidase chiitiko. Inogonawo kurambidza 5-α-reductase.
Zvidzidzo zvakati wandei zvinosanganisira zvidzidzo zvevanhu zvakaongorora mabhenefiti angangove ekushandiswa kwepamusoro kwegreen tea. Kushandiswa kwepamusoro kwegreen tea emulsion inhibited 5-α-reductase uye yakakonzera kuderera kwehukuru hwe microcomedone mu microcomedonal acne. Muchikamu chiduku chemavhiki matanhatu evanhu kupatsanurwa-chiso chekudzidza, kirimu ine EGCG yakaderera hypoxia-inducible factor 1 α (HIF-1α) uye vascular endothelial growth factor (VEGF) kutaura, kuratidza kukwanisa kudzivirira telangiectasias. Muchidzidzo chemapofu maviri, ingave yegirini tii, chena tii, kana mota yakangoiswa kumagadziko evazvipiri gumi vane hutano. Ganda racho rakabva rasvibiswa ne 2 × minimal erythema dose (MED) ye solar-simulated UVR. Ganda biopsies kubva kunzvimbo idzi kwakaratidza kuti kushandiswa kwegirinhi kana chena yetii inobvisa inogona kuderedza zvakanyanya kupera kwemasero eLangerhans, zvichienderana neCD1a positivity. Paivawo nekudzivirira kwechikamu cheUV-induced oxidative DNA kukuvara, sezvinoratidzwa nekudzikira kwemazinga e8-OHdG. Muchidzidzo chakasiyana, vazvipiri vakuru makumi mapfumbamwe vakaiswa mumapoka matatu: Hapana kurapwa, topical green tea, kana topical white tea. Boka rimwe nerimwe rakakamurwazve muzvikamu zvakasiyana zvemwaranzi yeUV. Iyo in vivo sun protection factor yakawanikwa ikaita SPF 1.
3.6. Marigold
3.6.1. Nhoroondo, Kushandiswa, Zvikumbiro
Marigold, Calendula officinalis, chirimwa chine maruva chinonhuhwirira chine mikana yekurapa. Yakave ichishandiswa mukurapa kwechivanhu muEurope nekuUnited States semushonga wepamusoro wekutsva, mavanga, kucheka, uye mapundu. Marigold yakaratidzawo anticancer migumisiro mumurine mienzaniso ye-non-melanoma ganda kenza.
3.6.2. Kuumbwa uye Mechanism Yekuita
Izvo zvakakosha zvemakemikari zvinoumba marigolds steroids, terpenoids, yemahara uye esterified triterpene alcohols, phenolic acids, flavonoids, uye mamwe makomisheni. Kunyange zvazvo imwe ongororo yakaratidza kuti kushandiswa kwepamusoro kwemarigold kunotora kunogona kuderedza kuoma uye kurwadziwa kweradiation dermatitis muvarwere vanogamuchira mwaranzi yekenza yemazamu, mimwe miedzo yekiriniki yakaratidza hukuru kana ichienzaniswa nekushandiswa kweaqueous cream chete.
3.6.3. Uchapupu hweSainzi
Marigold ine yakaratidza antioxidant kugona uye cytotoxic mhedzisiro pamasero egomarara remunhu mune in vitro yeganda remunhu cell modhi. Mune imwe yakasiyana in vitro yekudzidza, kirimu ine calendula mafuta yakaongororwa kuburikidza neUV spectrophotometric uye yakawanikwa iine mutsara wekutora muhuwandu hwe290-320 nm; izvi zvakatorwa kureva kuti kuiswa kwekrimu iyi kwaipa sun protection yakanaka. Zvakakosha kuziva, zvisinei, kuti iyi yanga isiri in vivo bvunzo iyo yakaverengera diki erythema dose muvanhu vanozvipira uye hazvisati zvanyatsojeka kuti izvi zvaizoshandura sei mumakiriniki ekuedzwa.
Mune in vivo murine modhi, marigold extract yakaratidza yakasimba antioxidant effect mushure mekuratidzwa kweUV. Muchidzidzo chakasiyana, chinosanganisira rats albino, kushandiswa kwepamusoro kwe calendula mafuta anokosha akadzikisa malondialdehyde (chiratidzo che oxidative stress) apo kuwedzera mazinga e catalase, glutathione, superoxide dismutase, uye ascorbic acid muganda.
Muchidzidzo chemavhiki masere chimwechete-bofu nezvidzidzo zvevanhu makumi maviri nerimwe, kushandiswa kwecalendula cream kumatama kwakawedzera kuoma kweganda asi kwakanga kusina migumisiro inokosha pahutano hweganda.
Chinhu chinogona kumisa kushandiswa kwemarigold mune zvekuzora ndechekuti marigold ndiyo inozivikanwa inokonzera allergic contact dermatitis, kufanana nedzimwe nhengo dzakawanda dzemhuri yeCompositae.
3.7. Damba
3.7.1. Nhoroondo, Kushandiswa, Zvikumbiro
Pomegranate, Punica granatum, ine simba rinopesana ne antioxidant uye yakashandiswa muzvigadzirwa zvakawanda senge topical antioxidant. Yayo yakakwira antioxidant yemukati inoita kuti ive inonakidza inogoneka musanganiswa mukuumbwa kwezvizoro.
3.7.2. Kuumbwa uye Mechanism Yekuita
The biologically inoshanda zvikamu zvepomegraneti tannins, anthocyanins, ascorbic acid, niacin, potassium, uye piperidine alkaloids. Izvi biologically active components zvinogona kutorwa kubva mujusi, mhodzi, peel, bark, mudzi, kana dzinde repomegranate. Zvimwe zvezvikamu izvi zvinofungidzirwa kuti zvine antitumor, anti-inflammatory, anti-microbial, antioxidant, uye photoprotective effects. Uyezve, pomegranate ndiyo ine simba sosi ye polyphenols. Ellegic acid, chikamu chepomegranate yakabudiswa, inogona kuderedza ganda reganda. Nekuda kwekuvimbisa kupikisa kuchembera, zvidzidzo zvakawanda zvakatsvaga nzira dzekuwedzera kupinda kweganda rekomboni iyi kuti ishandiswe pamusoro.
3.7.3. Uchapupu hweSainzi
Muchero wepomegranate unodzivirira fibroblasts yevanhu, in vitro, kubva kune UV-induced cell death; zvichida nekuda kwekuderera kwekuita kweNF-κB, kuderedzwa kweproapoptotic caspace-3, uye kuwedzera kweDNA kugadzirisa. Inoratidza anti-skin-tumor inokurudzira migumisiro mu vitro uye inhibits UVB-induced modulation yeNF-κB uye MAPK nzira. Topical application yepomegranate rind inobvisa inodzika COX-2 muganda renguruve richangobva kubviswa, zvichikonzera zvakakosha anti-inflammatory effects. Kunyange zvazvo ellegic acid inowanzofungidzirwa kuti ndiyo inonyanya kushanda yepomegranate extract, murine modhi yakaratidza basa rakakwirira rinopesana nekuputira rine mapomegranate rind extract yakaenzaniswa ne ellegic acid chete. Kushandiswa kwepamusoro-soro kwe microemulsion yepomegranate yakabudiswa uchishandisa polysorbate surfactant (Tween 80®) muvhiki gumi nembiri yakaparadzana-chiso kuenzanisa nezvidzidzo zve11, yakaratidza kuderera kwe melanin (nekuda kwe tyrosinase inhibition) uye yakaderera erythema kana ichienzaniswa nekutonga kwemotokari.
3.8. Soy
3.8.1. Nhoroondo, Kushandiswa, Zvikumbiro
Soya bhinzi chikafu chine mapuroteni ane bioactive izvo zvinogona kunge zvine anti-kuchembera. Kunyanya, soya bhinzi yakakwira mune isoflavones, iyo inogona kunge ine anticarcinogenic mhedzisiro uye estrogen-semhedzisiro nekuda kweiyo diphenolic chimiro. Iyi estrogen-senge mhedzisiro inogona kurwisa zvimwe zvinokonzeresa zvekuenda kumwedzi pakukwegura kweganda.
3.8.2. Kuumbwa uye Mechanism Yekuita
Soya, kubva kuGlycine maxi, ine mapuroteni akawanda uye ine isoflavones, kusanganisira glycitein, equol, daidzein, uye genistein. Aya isoflavones, anonziwo phytoestrogens, anogona kunge ane estrogenic mhedzisiro muvanhu.
3.8.3. Uchapupu hweSainzi
Soya bhinzi ine akawanda isoflavone ane anogona kudzivirira kuchembera mabhenefiti. Pakati pezvimwe zvinokonzerwa nehupenyu, glycitein inoratidza antioxidant migumisiro. Dermal fibroblasts inobatwa neglycitein yakaratidza kuwedzera kwesero kuwedzera uye kutama, yakawedzera synthesis ye collagen marudzi I uye III, uye yakaderera MMP-1. Muchidzidzo chakasiyana, soy extract yakasanganiswa nehematococcus extract (yemvura yakachena algae zvakare yakakwirira mu antioxidants), iyo yakaderedza MMP-1 mRNA uye mapuroteni kutaura. Daidzein, soy isoflavone, yakaratidza anti-wrinkle, ganda-kupenya, uye ganda-hydrating mhedzisiro. Diadzein inogona kushanda nekuita iyo estrogen-receptor-β muganda, zvichikonzera kuwedzeredzwa kwekutaura kwe endogenous antioxidants uye kuderera kwekutaura kwezvinhu zvekunyora izvo zvinotungamira kukuwedzera keratinocyte uye kutama. Iyo soy-yakatorwa isoflavonoid equol yakawedzera collagen uye elastin uye yakadzikira MMPs muchitokisi tsika.
Kuwedzera mu vivo murine zvidzidzo zvinoratidza kuderera kweUVB-induced cell death uye kuderera kwe epidermal ukobvu mumasero mushure mekushandiswa kwepamusoro kwezvinyorwa zve isoflavone. Muchidzidzo chemutyairi chevakadzi makumi matatu vepashure memenopausal, kutonga nemuromo kweisoflavone yakatorwa kwemwedzi mitanhatu kwakakonzera kuwedzera epidermal ukobvu uye kuwedzera dermal collagen sekuyerwa neganda biopsies munzvimbo dzakadzivirirwa nezuva. Muchidzidzo chakasiyana, yakacheneswa soya isoflavones yakavharira UV-induced keratinocyte kufa uye yakadzikira TEWL, epidermal ukobvu, uye erythema muUV-yakafumurwa mbeva ganda.
Anotarisirwa kaviri-mapofu RCT yevakadzi ve30 vane makore 45-55 vakaenzanisa kushandiswa kwepamusoro kweesrogen uye genistein (soy isoflavone) paganda kwemavhiki makumi maviri nemana. Kunyangwe boka raishandisa estrogen paganda raive nemhedzisiro yepamusoro, mapoka ese ari maviri airatidza yakawedzera mhando I uye III kumeso collagen zvichibva paganda biopsies re preauricular ganda. Soy oligopeptides inogona kuderedza erythema index muUVB-yakafumurwa ganda (forearm) uye kuderedza kupisa kwezuva uye cyclobutene pyrimidine dimers mu UVB-irradiated foreskin cells ex vivo. Muyedzo wekiriniki wakapetwa kaviri-mapofu-inodzorwa 12-vhiki yekiriniki inosanganisira 65 zvidzidzo zvechikadzi zvine mwero kumeso fotodamage yakaratidza kuvandudzwa kwe-mottled pigmentation, blotchiness, dullness, mitsetse yakanaka, kuumbwa kweganda, uye toni yeganda kana ichienzaniswa nemotokari. Pamwe chete, zvinhu izvi zvinogona kupa zvinogona kurwisa-kuchembera mhedzisiro, asi zvakanyanya kurongeka zviedzo zvekiriniki zvinodikanwa kuratidza zvakakwana kubatsira kwayo.
4. Kukurukurirana
Zvigadzirwa zveBotanical, zvinosanganisira izvo zvakurukurwa pano, zvine zvinogona kurwisa kuchembera. Maitiro eanorwisa-kuchembera botanicals anosanganisira yemahara radical scavenging mukana weiyo antioxidants yakaiswa pamusoro, yakawedzera dziviriro yezuva, yakawedzera kunyorova kweganda, uye akawanda mhedzisiro inotungamira mukuwedzera collagen kuumbwa kana kuderera kwe collagen kuparara. Mimwe yemigumisiro iyi ine mwero kana ichienzaniswa nemishonga, asi izvi hazviregi kubatsirwa kwavo kwazvinogona kana zvichishandiswa pamwe chete nemamwe matanho akadai sekudzivirira zuva, kushandiswa kwezuva, kunyorova kwezuva nezuva uye kurapwa kwakakodzera kwechiremba kwemamiriro ezvinhu eganda aripo.
Pamusoro pezvo, botanicals inopa zvimwe biologically active ingredients kune varwere vanosarudza kushandisa chete "zvakasikwa" zvinongedzo paganda ravo. Kunyange zvazvo zvinhu izvi zvinowanikwa mumasikirwo, zvakakosha kusimbisa kune varwere kuti izvi hazvirevi kuti zvinhu izvi zvine zero zvinokanganisa, chaizvoizvo, zvigadzirwa zvakawanda zvebhotani zvinozivikanwa kuti zvinogona kukonzera allergic contact dermatitis.
Sezvo zvigadzirwa zvekuzora zvisingade mwero wakafanana wehumbowo kuratidza kushanda, zvinowanzonetsa kuona kana zvirevo zvekurwisa kuchembera ndezvechokwadi. Mazhinji e botanicals akanyorwa pano, zvisinei, ane zvinogona kurwisa-kuchembera mhedzisiro, asi yakawanda yakasimba miedzo yekiriniki inodiwa. Kunyangwe zvakaoma kufanotaura kuti aya ma botanical agents achabatsira sei varwere nevatengi mune ramangwana, zvine mukana wekuti kune mazhinji eiyi botanicals, magadzirirwo anoabatanidza sezvimiro acharamba achiunzwa sezvigadzirwa zvekuchengetedza ganda uye kana chengetedza yakafara muganho wekuchengetedza, kugamuchirwa kwevatengi kwakanyanya, uye kugona kwakaringana, ivo vanozoramba vari chikamu chenguva dzose chekuchengetedza ganda maitiro, zvichipa mashoma mabhenefiti kuhutano hweganda. Kune huwandu hushoma hweava botanical agents, zvisinei, kukanganisa kukuru kune ruzhinji kunogona kuwanikwa nekusimbisa humbowo hwekuita kwavo kwebiology, kuburikidza neyakajairwa yakakwira throughput biomarker assays uye ipapo kuisa zvinonangwa zvinonyanya kuvimbiswa kuongororwa kwekiriniki kuyedzwa.
Nguva yekutumira: May-11-2023
