Sezvo ganda richikura, pane kudzikira kwebasa remuviri. Shanduko idzi dzinokonzereswa nezvinhu zviri mukati (zvenguva) uye zvekunze (zvinonyanya kukonzerwa neUV). Botanicals dzinopa mabhenefiti anogona kurwisa zvimwe zvezviratidzo zvekukwegura. Pano, tinoongorora botanicals dzakasarudzwa uye humbowo hwesainzi huri shure kwezvinotaurwa kuti dzinorwisa kukwegura. Botanicals dzinogona kupa anti-inflammatory, antioxidant, moisturizing, UV-protective, nezvimwe. Botanicals dzakawanda dzakanyorwa sezvinhu zviri muzvizoro zvakakurumbira uye cosmeceuticals, asi shoma chete dzakasarudzwa ndidzo dzinokurukurwa pano. Izvi zvakasarudzwa zvichibva pakuwanikwa kwedata resainzi, kufarira kwevanyori, uye "kufarirwa" kwezvinhu zvezvizoro nezvizoro zviripo pari zvino. Botanicals dzakaongororwa pano dzinosanganisira argan oil, coconut oil, crocin, feverfew, green tea, marigold, pomegranate, uye soy.
Mashoko akakosha: botanical; anti-aging; argan oil; kokonati oil; crocin; feverfew; green tea; marigold; pomegranate; soy
3.1. Oiri yeArgan
3.1.1. Nhoroondo, Mashandisirwo, uye Zvikumbiro
Mafuta eArgan anowanikwa kuMorocco uye anogadzirwa kubva kumbeu dzeArgania sponosa L. Anoshandiswa nenzira dzakasiyana siyana dzakadai sekubika, kurapa hutachiona hweganda, uye kuchengetedza ganda nebvudzi.
3.1.2. Kuumbwa uye Maitiro Ekuita
Oiri yeArgan inoumbwa ne80% yemafuta asina kukora uye 20% yemafuta akazara uye ine polyphenols, tocopherols, sterols, squalene, uye triterpene alcohol.
3.1.3. Humbowo hweSainzi
Oiri yeArgan yagara ichishandiswa muMorocco kuderedza ruvara rwechiso, asi hwaro hwesainzi hweizvi hwakanga husinganzwisiswi kare. Mukudzidza kwembeva, oiri yeArgan yakadzivisa tyrosinase uye dopachrome tautomerase kuratidzwa mumasero eB16 murine melanoma, zvichikonzera kudzikira kwehuwandu hwemelanin zvichienderana nedosi. Izvi zvinoratidza kuti oiri yeArgan inogona kunge iri chinhu chinodzivirira melanin biosynthesis, asi miedzo yekudzora yakasarudzika (RTC) muvanhu inodiwa kuti isimbise fungidziro iyi.
RTC diki yevakadzi makumi matanhatu vakapedza kuenda kumwedzi yakaratidza kuti kunwa mafuta e argan zuva nezuva uye/kana kuiswa pamusoro peganda kunoderedza kurasikirwa nemvura mu transepidermal (TEWL), kuwedzera kusimba kweganda, zvichibva pakuwedzera kweR2 (gross elasticity yeganda), R5 (net elasticity yeganda), uye R7 (biological elasticity) parameters uye kudzikira kwe resonance running time (RRT) (chiyero chakabatana nekusimba kweganda). Mapoka aya akasarudzirwa kushandisa mafuta emuorivhi kana argan oil. Mapoka ese ari maviri akashandisa mafuta e argan kuruboshwe rwevolar chete. Kuyerwa kwakatorwa kubva kurudyi nekuruboshwe rwevolar. Kuvandudzika kwekusimba kwakaonekwa mumapoka ese ari maviri paruoko apo mafuta e argan akaiswa pamusoro, asi paruoko apo mafuta e argan asina kushandiswa chete boka raidya mafuta e argan rakawedzera kusimba [31]. Izvi zvakakonzerwa nekuwedzera kwehuwandu hwe antioxidant mumafuta e argan zvichienzaniswa nemafuta emuorivhi. Zvinofungidzirwa kuti izvi zvinogona kunge zvichikonzerwa nehuwandu hwayo hweVitamin E ne ferulic acid, ayo anozivikanwa se antioxidants.
3.2. Mafuta eKokonati
3.2.1. Nhoroondo, Mashandisirwo, uye Zvikumbiro
Mafuta ekokonati anobva kumuchero wakaomeswa weCocos nucifera uye ane mashandisirwo akawanda, ekare neemazuva ano. Anoshandiswa semushonga wekunhuhwirira, ganda, uye kugadzirisa bvudzi, uye muzvigadzirwa zvakawanda zvekushongedza. Kunyange zvazvo mafuta ekokonati aine zvinhu zvakawanda zvinobva mairi, zvinosanganisira coconut acid, hydrogenated coconut acid, uye hydrogenated coconut oil, tichakurukura nezvezvinotaurwa neongororo zvine chekuita nemafuta ekokonati (VCO), ayo anogadzirwa pasina kupisa.
Mafuta ekokonati ave achishandiswa kunyorovesa ganda revana uye anogona kubatsira pakurapa atopic dermatitis nekuda kwehunhu hwayo hwekunyorovesa uye mhedzisiro yayo paStaphylococcus aureus nedzimwe hutachiona hweganda muvarwere vane atopic dermatitis. Mafuta ekokonati akaratidzwa kuti anoderedza S. aureus colonization paganda revanhu vakuru vane atopic dermatitis muRTC ine double-blind.
3.2.2. Kuumbwa uye Maitiro Ekuita
Mafuta ekokonati anoumbwa ne90–95% yemafuta akazara (lauric acid, myristic acid, caprylic acid, capric acid, uye palmitic acid). Izvi zvakasiyana nemafuta mazhinji emuriwo/michero, ayo anonyanya kuumbwa nemafuta asina mafuta. Mafuta akazara anoiswa pamusoro anoshanda kunyorovesa ganda sechinonhuhwirira nekubvisa mipendero yakaoma yakakombama ye corneocytes uye kuzadza mipata iri pakati pawo.
3.2.3. Humbowo hweSainzi
Mafuta ekokonati anogona kunyorovesa ganda rakaoma rinokura. Makumi matanhatu nemaviri muzana emafatty acids ari muVCO akafanana uye 92% akazara, izvo zvinoita kuti pave nekuputira kwakasimba kunoita kuti pave nemhedzisiro yakakura yekuvhara kupfuura mafuta emuorivhi. Ma triglycerides ari mumafuta ekokonati anopatsanurwa ne lipases mumiti yeganda yakajairika kuenda ku glycerin ne fatty acids. Glycerin inhuhwirira ine simba, inokwevera mvura ku cornea layer ye epidermis kubva kunze uye mukati meganda. Mafuta e fatty acids ari muVCO ane huwandu hwakaderera hwe linoleic acid, izvo zvakakosha sezvo linoleic acid inogona kutsamwisa ganda. Mafuta ekokonati anopfuura mafuta eminerali mukuderedza TEWL muvarwere vane atopic dermatitis uye anoshanda uye akachengeteka semafuta eminerali mukurapa xerosis.
Lauric acid, iyo inotangira monolaurin uye chikamu chakakosha cheVCO, inogona kunge iine hunhu hwekudzivirira kuzvimba, inokwanisa kugadzirisa kuwanda kwemasero emuviri uye inokonzera mamwe emhedzisiro yeVCO. VCO ine huwandu hwakawanda hwe ferulic acid ne p-coumaric acid (ese ari phenolic acids), uye huwandu hwakawanda hwe phenolic acids idzi hunobatanidzwa nekuwanda kwe antioxidant. Phenolic acids inoshanda pakurwisa kukuvara kunokonzerwa ne UV. Zvisinei, pasinei nezvinotaurwa kuti mafuta ekokonati anogona kushanda se sunscreen, zvidzidzo zve in vitro zvinoratidza kuti haina mukana wekudzivirira UV zvakanyanya.
Pamusoro pekuita kwayo kunyorovesa uye kuuraya mabhakitiriya, mhando dzemhuka dzinoratidza kuti VCO inogona kuderedza nguva yekupora kwemaronda. Kwakanga kune huwandu hwakakwira hwe pepsin-soluble collagen (higher collagen cross-linking) mumaronda akarapwa neVCO zvichienzaniswa nevanorapa. Histopathology yakaratidza kuwedzera kwekuwedzera kwefibroblast uye neovascularization mumaronda aya. Zvidzidzo zvakawanda zvinodiwa kuti zvione kana kushandiswa kweVCO pamusoro peganda kuchigona kuwedzera huwandu hwecollagen muganda revanhu rinokwegura.
3.3. Crocin
3.3.1. Nhoroondo, Mashandisirwo, Zvikumbiro
Crocin chikamu chesaffron chinoshanda muhupenyu, chinobva mukusagadzikana kwakaomeswa kweCrocus sativus L. Saffron inorimwa munyika dzakawanda dzinosanganisira Iran, India, neGreece, uye yakashandiswa mukurapa kwechivanhu kuderedza zvirwere zvakasiyana-siyana zvinosanganisira kuora mwoyo, kuzvimba, chirwere chechiropa, nezvimwe zvakawanda.
3.3.2. Kuumbwa uye Maitiro Ekuita
Crocin ndiyo inoita kuti ruvara rwesafroni ruve ruvara. Crocin inowanikwawo mumuchero weGardenia jasminoides Ellis. Inoiswa muboka re carotenoid glycoside.
3.3.3. Humbowo hweSainzi
Crocin ine simba rekudzivirira muviri, inodzivirira squalene kubva kuUV-induced peroxidation, uye inodzivirira kuburitswa kwezvinorwisa muviri. Simba rekudzivirira muviri rakaratidzwa muongororo dze in vitro dzakaratidza kushanda kwepamusoro kweantioxidant zvichienzaniswa neVitamin C. Pamusoro pezvo, crocin inodzivirira UVA-induced cell membrane peroxidation uye inodzivirira kutaura kwezvinorwisa muviri zvakawanda zvinosanganisira IL-8, PGE-2, IL-6, TNF-α, IL-1α, uye LTB4. Inoderedzawo kutaura kwemajini akawanda anotsigira NF-κB. Muchidzidzo chakashandisa fibroblasts dzevanhu dzakakura, crocin yakaderedza UV-induced ROS, yakasimudzira kutaura kwe extracellular matrix protein Col-1, uye yakaderedza huwandu hwemasero ane senescent phenotypes mushure memwaranzi yeUV. Inoderedza kugadzirwa kweROS uye inoderedza apoptosis. Crocin yakaratidzwa kudzvinyirira nzira dzechiratidzo dzeERK/MAPK/NF-κB/STAT mumasero eHaCaT in vitro. Kunyangwe crocin iine mukana wekudzivirira kukwegura kwemasero, chinhu ichi hachina basa. Kushandiswa kwemafuta akapatsanurwa nemuviri (nanostructured lipid dispersions) pakuiswa kwemuviri kwakaongororwa nemhedzisiro yakanaka. Kuti zvionekwe kuti crocin inogona sei kushandiswa mumuviri, mamwe marudzi emhuka uye miedzo yekiriniki yakasarudzika inodiwa.
3.4. Fivha
3.4.1. Nhoroondo, Mashandisirwo, Zvikumbiro
Feverfew, Tanacetum parthenium, igwenzi risingaperi rinowanzoshandiswa mukurapa kwevanhu.
3.4.2. Kuumbwa uye Maitiro Ekuita
Feverfew ine parthenolide, sesquiterpene lactone, iyo inogona kunge iri iyo inokonzeresa mamwe emhedzisiro yayo yekudzivirira kuzvimba, kuburikidza nekudzivisa NF-κB. Kudzivirira uku kweNF-κB kunoita sekunge hakuna chekuita nemhedzisiro ye parthenolide yekudzivirira muviri. Parthenolide yakaratidzawo mhedzisiro yekurwisa kenza kurwisa kenza yeganda inokonzerwa neUVB uye kurwisa masero e melanoma in vitro. Zvinosuwisa kuti parthenolide inogona zvakare kukonzera allergic reactions, mablisters emuromo, uye allergic contact dermatitis. Nekuda kweizvi, ikozvino inowanzo bviswa feverfew isati yawedzerwa kuzvigadzirwa zvekushongedza.
3.4.3. Humbowo hweSainzi
Nekuda kwematambudziko anogona kuitika nekushandisa parthenolide pamusoro peganda, zvimwe zvigadzirwa zvekushongedza zvine feverfew zvinoshandisa parthenolide-depleted feverfew (PD-feverfew), iyo inoti haina simba rekudzivirira. PD-feverfew inogona kuwedzera basa rekugadzirisa DNA muganda, zvichigona kuderedza kukuvara kweDNA kunokonzerwa neUV. Muchidzidzo che in vitro, PD-feverfew yakaderedza kuumbwa kwehydrogen peroxide inokonzerwa neUV uye yakaderedza kuburitswa kwe cytokine inodzivirira kuzvimba. Yakaratidza mhedzisiro yakasimba yeantioxidant kupfuura Vitamin C, uye yakaderedza erythema inokonzerwa neUV muRTC yevanhu gumi nevaviri.
3.5. Tii yegirini
3.5.1. Nhoroondo, Mashandisirwo, Zvikumbiro
Tii yegirini yagara ichinwiwa muChina nekuda kwekubatsira kwayo pahutano kwemazana emakore. Nekuda kwesimba rayo rekudzivirira muviri, pane kufarira kugadzirwa kwemushonga wakasimba, unowanikwa mumuviri.
3.5.2. Kuumbwa uye Maitiro Ekuita
Tiyi yegirini, inobva kuCamellia sinensis, ine mishonga yakawanda inoshanda mumuviri ine simba rekudzivirira kukwegura, kusanganisira caffeine, mavhitamini, uye polyphenols. Mapolyphenols makuru ari mutiyi yegirini i catechins, kunyanya gallocatechin, epigallocatechin (ECG), uye epigallocatechin-3-gallate (EGCG). Epigallocatechin-3-gallate ine antioxidant, photoprotective, immunomodulatory, anti-angiogenic, uye anti-inflammatory. Tiyi yegirini inewo huwandu hwakawanda hwe flavonol glycoside kaempferol, iyo inonyudzwa zvakanaka muganda mushure mekuisirwa pamusoro.
3.5.3. Humbowo hweSainzi
Mushonga wetii yegirini unoderedza kugadzirwa kweROS mukati memasero mumuviri uye waderedza necrosis inokonzerwa neROS. Epigallocatechin-3-gallate (polyphenol yetii yegirini) inodzivirira kuburitswa kwehydrogen peroxide inokonzerwa neUV, inoderedza phosphorylation yeMAPK, uye inoderedza kuzvimba kuburikidza nekushanda kweNF-κB. Uchishandisa ganda remukadzi ane makore makumi matatu nerimwe ekuberekwa ane hutano, ganda rakarapwa kare nechinhu chichena kana chegirini chetii chakaratidza kuchengetedza masero eLangerhans (masero anogadzira antigen anokonzera kupinza kwekudzivirira muviri muganda) mushure mekuvhenekerwa nechiedza cheUV.
Mumuenzaniso wembeva, kuiswa kwegreen tea extract pamusoro peganda risati rasviba UV kwakaita kuti erythema iderere, ma leukocytes apinde muganda, uye myeloperoxidase activity iderere. Zvinogonawo kudzivirira 5-α-reductase.
Zvidzidzo zvakasiyana-siyana zvinosanganisira vanhu zvakaongorora mabhenefiti angangowanikwa nekushandisa green tea pamusoro. Kuisa green tea emulsion pamusoro kwakadzivirira 5-α-reductase uye kwakakonzera kudzikira kwehukuru hwe microcomedone mu microcomedonal acne. Mukudzidza kudiki kwemavhiki matanhatu kwevanhu kwakapatsanurwa kumeso, kirimu ine EGCG yakaderedza hypoxia-inducible factor 1 α (HIF-1α) uye vascular endothelial growth factor (VEGF) expression, zvichiratidza mukana wekudzivirira telangiectasias. Mukudzidza kwakaitwa kaviri, green tea, white tea, kana vehicle chete zvakaiswa kumagaro evanhu gumi vane hutano hwakanaka. Ganda rakazopiswa ne 2× minimal erythema dose (MED) ye solar-simulated UVR. Skin biopsies kubva munzvimbo idzi dzakaratidza kuti kushandiswa kwegreen tea extract kana white tea kunogona kuderedza zvakanyanya kupera kweLangerhans cells, zvichibva paCD1a positivity. Kwakanga kunewo kudzivirira zvishoma kweUV-induced oxidative DNA damage, sezvinoratidzwa nekudzikira kwe8-OHdG. Mune imwe ongororo yakasiyana, vanhu vakuru makumi mapfumbamwe vakazvidira vakaiswa mumapoka matatu: Hapana mushonga, tii yegirini inotorwa kubva kuganda, kana tii chena inotorwa kubva kuganda. Boka rega rega rakakamurwa kuita mwero wakasiyana wemwaranzi yeUV. Chinhu chinodzivirira zuva kubva kuganda chakawanikwa chiri paSPF 1.
3.6. Marigold
3.6.1. Nhoroondo, Mashandisirwo, Zvikumbiro
Marigold, Calendula officinalis, chirimwa chinotumbuka maruva chinonhuhwirira chine mikana yekurapa. Chave chichishandiswa mukurapa kwevanhu muEurope nemuUnited States semushonga wekurapa kutsva, mavanga, maronda, uye mapundu. Marigold yakaratidzawo mhedzisiro yekurwisa kenza mumhando dzegomarara reganda risiri melanoma.
3.6.2. Kuumbwa uye Maitiro Ekuita
Zvikamu zvikuru zvemakemikoro emarigolds isteroids, terpenoids, triterpene alcohols dzisina kuchena uye dzakagadzirwa, phenolic acids, flavonoids, nezvimwe zvinhu. Kunyangwe imwe ongororo yakaratidza kuti kushandiswa kwemarigold extract pamusoro pemvura kunogona kuderedza kuomarara uye marwadzo e radiation dermatitis muvarwere vanogamuchira radiation yekenza yemazamu, mimwe miedzo yekiriniki yakaratidza kuti hapana kunaka kana tichienzanisa nekushandisa aqueous cream chete.
3.6.3. Humbowo hweSainzi
Marigold ine simba rekudzivirira kenza uye ine chepfu pamasero ekenza evanhu mumuenzaniso wemasero eganda revanhu mu vitro. Mune imwe ongororo yakaitwa mu vitro, kirimu ine calendula oil yakaongororwa kuburikidza neUV spectrophotometric uye yakawanikwa ine absorbance spectrum iri pakati pe290-320 nm; izvi zvakatorwa zvichireva kuti kushandisa kirimu iyi kwaidzivirira zuva zvakanaka. Zvisinei, zvakakosha kuziva kuti iyi yakanga isiri bvunzo ye in vivo yakaverenga dose shoma ye erythema muvanhu vanozvipira uye hazvisati zvajeka kuti izvi zvaizoshandurwa sei mumiedzo yekiriniki.
Mune imwe ongororo yemurine ye in vivo, marigold extract yakaratidza simba guru rekuchengetedza mabhakitiriya mushure mekusvikwa neUV. Mune imwe ongororo, yaisanganisira makonzo ealbino, kushandiswa kwemafuta e calendula essential oil pamusoro peganda kwakaderedza malondialdehyde (chiratidzo chekushushikana kwe oxidative) ukuwo kuchiwedzera huwandu hwe catalase, glutathione, superoxide dismutase, uye ascorbic acid muganda.
Muongororo yevhiki sere yakaitwa nevanhu makumi maviri nerimwe vasina kuona, kushandisa calendula cream pamatama kwakawedzera kuoma kweganda asi hakuna kukanganisa zvakanyanya ganda.
Chimwe chinhu chingangokanganisa kushandiswa kwemarigold muzvizoro ndechekuti marigold inozivikanwa sechikonzero cheallergy contact dermatitis, sevamwe vanhu vakawanda vemumhuri yeCompositae.
3.7. Pomegranate
3.7.1. Nhoroondo, Mashandisirwo, Zvikumbiro
Pomegranate, Punica granatum, ine simba guru rekuchengetedza ganda uye yakashandiswa muzvigadzirwa zvakasiyana-siyana se antioxidant yemushonga wepamusoro. Yakawanda mukuchengetedza ganda inoita kuti ive chinhu chinonakidza mukugadzirwa kwezvizoro.
3.7.2. Kuumbwa uye Maitiro Ekuita
Zvinhu zvinoshanda mumuviri wepomegranate zvinosanganisira tannins, anthocyanins, ascorbic acid, niacin, potassium, uye piperidine alkaloids. Izvi zvinhu zvinoshanda mumuviri zvinogona kubviswa kubva mumuto, mhodzi, ganda, bark, mudzi, kana hunde yepomegranate. Zvimwe zvezvinhu izvi zvinofungidzirwa kuti zvine simba rekudzivirira bundu, kudzivirira kuzvimba, kudzivirira hutachiona, antioxidant, uye photoprotective effects. Pamusoro pezvo, pomegranate inzvimbo ine simba yepolyphenols. Ellegic acid, chikamu chepomegranate extract, inogona kuderedza ruvara rweganda. Nekuda kwekuva chinhu chinodzivirira kukwegura, zvidzidzo zvakawanda zvakaongorora nzira dzekuwedzera kupinda kweganda remushonga uyu kuti ushandiswe paganda.
3.7.3. Humbowo hweSainzi
Muchero wepomegranate unodzivirira ma fibroblast emunhu, mu vitro, kubva pakufa kwemasero anokonzerwa neUV; zvichida nekuda kwekudzikira kwekushanda kweNF-κB, kudzikiswa kweproapoptotic caspace-3, uye kuwedzera kugadziriswa kweDNA. Unoratidza mhedzisiro inodzivirira bundu reganda mu vitro uye unodzivirira UVB-induced modulation yeNF-κB neMAPK pathways. Kushandiswa kwepomegranate rind extract pamusoro kunoderedza COX-2 muganda renguruve richangobva kubviswa, zvichikonzera mhedzisiro yakakosha yekudzivirira kuzvimba. Kunyangwe ellegic acid ichiwanzofungidzirwa kuti ndiyo inonyanya kushanda mupomegranate extract, murine model yakaratidza kushanda kwakanyanya kwekudzivirira kuzvimba ne standardized pomegranate rind extract zvichienzaniswa ne ellegic acid chete. Kushandiswa kwe microemulsion yepomegranate extract pamusoro uchishandisa polysorbate surfactant (Tween 80®) mukuenzanisa kwemavhiki gumi nemaviri nevanhu gumi nerimwe, kwakaratidza kudzikira kwe melanin (nekuda kwe tyrosinase inhibition) uye kudzikira kwe erythema zvichienzaniswa ne vehicle control.
3.8. Soya
3.8.1. Nhoroondo, Mashandisirwo, Zvikumbiro
Soya chikafu chine mapuroteni akawanda chine zvinhu zvinobatsira muviri zvinogona kuva nemigumisiro inodzivirira kukwegura. Kunyanya, soya dzine isoflavones yakawanda, iyo inogona kuva nemigumisiro inodzivirira kenza uye mhedzisiro yakafanana neestrogen nekuda kwechimiro che diphenolic. Migumisiro iyi yakafanana neestrogen inogona kurwisa zvimwe zvemigumisiro yekuguma kuenda kumwedzi pakukwegura kweganda.
3.8.2. Kuumbwa uye Maitiro Ekuita
Soya, inobva kuGlycine maxi, ine mapuroteni akawanda uye ine ma isoflavones, anosanganisira glycitein, equol, daidzein, uye genistein. Ma isoflavones aya, anonziwo phytoestrogens, anogona kuva nemigumisiro ye estrogenic muvanhu.
3.8.3. Humbowo hweSainzi
Soya ine ma isoflavones akawanda ane mukana wekubatsira mukudzivirira kukwegura. Pakati pezvimwe zvinokonzeresa zvipenyu, glycitein inoratidza mhedzisiro ye antioxidant. Ma fibroblast eganda akarapwa ne glycitein akaratidza kuwedzera kwekukura kwemasero uye kufamba, kuwedzera kugadzirwa kwe collagen types I ne III, uye kudzikira kwe MMP-1. Mune imwe ongororo, soy extract yakabatanidzwa ne haematococcus extract (algae yemvura yakachena inewo ma antioxidants akawanda), izvo zvakaderedza MMP-1 mRNA uye protein expression. Daidzein, soy isoflavone, yakaratidza mhedzisiro yekudzivirira makunya, kujekesa ganda, uye kuchenesa ganda. Diadzein inogona kushanda nekuita kuti estrogen-receptor-β ishande muganda, zvichikonzera kuwedzera kwe endogenous antioxidants uye kudzikira kwe expression ye transcription factors inotungamira mukuwedzera uye kufamba kwe keratinocyte. Soy-derived isoflavonoid equol yakawedzera collagen ne elastin uye kudzikira kweMMPs mu cellular culture.
Zvimwe zvidzidzo zvemudumbu zvakaratidza kudzikira kwekufa kwemasero anokonzerwa neUVB uye kudzikira kweukobvu hweepidermal mumasero mushure mekushandiswa kweisoflavone extracts pamusoro peganda. Muchidzidzo chekutanga chevakadzi makumi matatu vapedza kuenda kumwedzi, kunwa isoflavone extract nemuromo kwemwedzi mitanhatu kwakaita kuti ukobvu hweepidermal huwedzere uye collagen yeganda iwedzere sezvakayerwa ne biopsies yeganda munzvimbo dzakadzivirirwa nezuva. Mune chimwe chidzidzo chakasiyana, soy isoflavones dzakacheneswa dzakadzivirira kufa kwekeratinocyte inokonzerwa neUV uye kudzikira kweTEWL, ukobvu hweepidermal, uye erythema muganda rembeva rakafumurwa neUV.
RCT yevakadzi makumi matatu vane makore makumi mana nemashanu kusvika makumi mashanu nemashanu yakaenzanisa kushandiswa kweestrogen negenistein (soy isoflavone) paganda kwemavhiki makumi maviri nemana. Kunyangwe boka rakashandisa estrogen paganda rakawana mhedzisiro yakanaka, mapoka ese ari maviri akaratidza kuwedzera kwerudzi rweI neIII facial collagen zvichibva paganda reganda risati rasvika. Soy oligopeptides inogona kuderedza erythema index muganda rakavhurika UVB (forearm) uye kuderedza masero akapiswa nezuva uye cyclobutene pyrimidine dimers mumasero epamberi akapiswa neUVB ex vivo. Kuedzwa kwekiriniki kwemavhiki gumi nemaviri kwakarongwa nemotokari kunosanganisira vakadzi makumi matanhatu nevashanu vane photodamage iri pakati nepakati yechiso kwakaratidza kuvandudzika mu pigmentation ine mavanga, mavanga, kusviba, mitsetse midiki, magadzirirwo eganda, uye ganda kana zvichienzaniswa nemotokari. Pamwe chete, zvinhu izvi zvinogona kupa mhedzisiro inogona kurwisa kukwegura, asi miedzo yakasimba yekiriniki inodiwa kuti iratidze zvakakwana kubatsira kwayo.
4. Kukurukurirana
Zvigadzirwa zvemiti, kusanganisira zvataurwa pano, zvinogona kukonzera kukwegura. Nzira dzemishonga yemiti ...
Pamusoro pezvo, mishonga yemiti inopa zvimwe zvinhu zvinoshanda mumuviri kune varwere vanosarudza kushandisa zvinhu "zvechisikigo" chete paganda ravo. Kunyangwe zvinhu izvi zvichiwanikwa muzvisikwa, zvakakosha kusimbisa varwere kuti izvi hazvirevi kuti zvinhu izvi hazvina migumisiro yakaipa, kutaura zvazviri, mishonga yemiti yakawanda inozivikanwa sechikonzero chinogona kukonzera allergic contact dermatitis.
Sezvo zvigadzirwa zvekushongedza zvisingade humbowo hwakafanana kuti zviratidze kushanda, zvinowanzova zvakaoma kuona kana zvinotaurwa nezvemigumisiro yekudzivirira kukwegura zviri zvechokwadi. Zvisinei, mimwe yemishonga yemiti yakanyorwa pano ine mhedzisiro yekudzivirira kukwegura, asi miedzo yakasimba yekiriniki inodiwa. Kunyangwe zvakaoma kufanotaura kuti mishonga iyi yemiti ichabatsira sei varwere nevatengi mune ramangwana, zvingangoita kuti kune vazhinji vemishonga iyi yemiti, mafomura ayo anosanganisira sezvinhu zvicharamba zvichiunzwa sezvigadzirwa zvekuchengetedza ganda uye kana zvikaramba zvakachengetedzeka, zvichigamuchirwa zvakanyanya nevatengi, uye zvichikwanisika kutenga, zvicharamba zviri chikamu chemaitiro ekuchengetedza ganda nguva dzose, zvichipa mabhenefiti mashoma kuhutano hweganda. Kune vashoma vemishonga iyi yemiti, zvisinei, kukanganisa kukuru kune vanhu vazhinji kunogona kuwanikwa nekusimbisa humbowo hwebasa rayo rezvemuviri, kuburikidza nekuyedzwa kwe biomarker kwakajairika uye mushure mezvo kuisa zvinangwa zvinovimbisa zvikuru pakuyedzwa kwekiriniki.
Nguva yekutumira: Chivabvu-11-2023
