Lycorine Hydrochloride
Lycorine hydrochloride ipfu chena kusvika yakasviba inobva kualkaloid lycorine, inowanikwa mumiti yeLycoris radiata (L'Her.), uye ndeyemhuri yeAmaryllidaceae. Lycorine hydrochloride ine mhedzisiro dzakasiyana-siyana dzemishonga, dzinosanganisira kurwisa bundu, kurwisa kenza, kurwisa HCV, kurwisa kuzvimba, kurwisa mabhakitiriya, kurwisa mavhairasi, kurwisa angiogenesis, uye kurwisa malaria. Inonyungudika mumvura, DMSO, uye ethanol. Maumbirwo ayo emakemikari anozivikanwa nechimiro chakaoma chesteroidal chine kuravira kunovava nemapoka akawanda anoshanda, anosanganisira hydroxyl uye amino groups, zvichibatsira mumabasa ayo ehupenyu.
| Zita rechigadzirwa | Lycorine hydrochloride CAS:2188-68-3 | ||
| Chitubu chezvirimwa | Lycoris | ||
| Mamiriro ekuchengetedza | Chengeta nechisimbiso patembiricha yemumba | Zuva remushumo | 2024.08.24 |
| Chinhu | Zvakajairika | Mhedzisiro |
| Kuchena()HPLC） | Lycorine hydrochloride≥98% | 99.7% |
| Chitarisiko | Upfu husina kuchena | Zvinoenderana |
| Hunhu hwemuviriics | ||
| Saizi yezvimedu | NLT100% 80Mesh | Zvinoenderana |
| Kurasikirwa pakuomeswa | ≤1.0% | 1.8% |
| Zvinorema simbi | ||
| Simbi dzese | ≤10.0ppm | Zvinoenderana |
| Tungamira | ≤2.0ppm | Zvinoenderana |
| Mercury | ≤1.0ppm | Zvinoenderana |
| Cadmium | ≤0.5ppm | Zvinoenderana |
| Zvipembenene | ||
| Huwandu hwebhakitiriya | ≤1000cfu/g | Zvinoenderana |
| Mbiriso | ≤100cfu/g | Zvinoenderana |
| Escherichia coli | Hazvina kubatanidzwa | Hazvina kuonekwa |
| Salmonella | Hazvina kubatanidzwa | Hazvina kuonekwa |
| Staphylococcus | Hazvina kubatanidzwa | Hazvina kuonekwa |
| Mhedziso | Anokodzera | |
Zvimiro:
(1) Kuchena Kwakanyanya:Chigadzirwa chedu chinogadziriswa zvakanaka kuti chive nechokwadi chekuti chakachena zvakanyanya, izvo zvakakosha pakushanda kwacho uye kuchengetedzeka mukushandiswa kwakasiyana-siyana.
(2) Hunhu hweKurwisa Gomarara:Yakaratidza mhedzisiro yakakosha yekurwisa kenza pamhando dzakasiyana dzekenza, mu vitro nemu vivo, kuburikidza nenzira dzakadai sekukurudzira kumisa kwemasero, kukonzera apoptosis, uye kudzivirira angiogenesis.
(3) Chiito Chine Chinangwa Chakawanda:Lycorine hydrochloride inofungidzirwa kuti inoshanda pamwe chete nemasero akawanda ekenza, zvichipa simba guru pakurwisa masero ekenza.
(4) Huturu Hushoma:Inoratidza chepfu shoma kumasero akajairwa, inova chinhu chakakosha pakushandiswa kwayo semushonga wekurapa.
(5) Nhoroondo yeMishonga:Mushonga uyu wakaongororwa kuti unoshanda sei pakurapa, zvichiratidza kuti unokurumidza kunyudzwa uye kubviswa nekukurumidza kubva muplasma, izvo zvakakosha pakuronga mushonga uye kuronga kurapwa.
(6) Mhedzisiro yekubatana:Lycorine hydrochloride yakaratidza mhedzisiro yakawedzerwa kana ikashandiswa pamwe chete nemimwe mishonga, izvo zvinogona kubatsira mukukunda kusakwanisa kushandisa mishonga uye kuvandudza mhedzisiro yekurapwa.
(7) Tsvagiridzo Inotsigirwa:Chigadzirwa ichi chinotsigirwa netsvakurudzo yakakura, zvichipa hwaro hwakasimba hwekushandiswa kwacho mukugadzirwa kwemishonga uye kushandiswa kwekiriniki.
(8) Kuvimbisa Hunhu:Matanho akasimba ekudzora mhando aripo panguva yese yekugadzira kuitira kuve nechokwadi chekuti chigadzirwa chacho chakasimba uye chakavimbika.
(9) Mashandisirwo Anoshandiswa Pakuchinja-chinja:Yakakodzera kushandiswa mukutsvagisa nekugadzira mishonga, kusanganisira kuwanikwa kwemishonga uye kugadzirwa kwekurapa kenza.
(10) Kutevedzera mitemo:Yakagadzirwa zvichienderana nezvinodiwa neGMP kuti ive nechokwadi chekuti chigadzirwa chacho chakachengeteka uye chinoshanda zvakanaka.
(1) Indasitiri yemishonga:Lycorine hydrochloride inoshandiswa mukugadzira mishonga inorwisa mavhairasi uye inorwisa kenza.
(2) Indasitiri yeBiotechnology:Inoshandiswa mukutsvaga nekugadzira mishonga mitsva yekurapa uye mishonga yekurapa.
(3) Kutsvaga zvigadzirwa zvechisikigo:Lycorine hydrochloride inodzidzwa nekuda kwekubatsira kwayo pahutano uye hunyanzvi hwayo hwekurapa.
(4) Indasitiri yemakemikari:Inogona kushandiswa sechikamu chemakemikari mukugadzirwa kwemamwe makemikari.
(5) Indasitiri yekurima:Lycorine hydrochloride yakaongororwa kuti inogona sei kushandiswa semushonga wezvipembenene uye mudziviriri wekukura kwezvirimwa.
Maitiro ekubvisa lycorine hydrochloride anowanzo sanganisira matanho akakosha anotevera ekuona kuchena kwe solvent uye kuvandudza mwero wekupora:
(1) Kusarudzwa kwezvinhu zvisina kugadzirwa uye kurapwa kwacho nguva isati yasvika:Sarudza zvinhu zvekurima zveAmaryllidaceae zvakakodzera, zvakaita semababu eAmaryllis, wozvigeza, woomesa wozvipwanya kuti uve nechokwadi chekuti zvinhu zvekurima zvakachena uye woisa hwaro hwekuzobvisa zvimwe zvinhu.
(2)Kurapa kwekutanga kwe enzyme yakagadzirwa:Shandisa ma enzymes akaomarara (akadai se cellulase ne pectinase) kuti ugadzirise zvinhu zvakapwanywa kuti zviore madziro emasero emiti uye uvandudze kushanda zvakanaka kwekuburitsa zvinhu.
(3)Sanganisa hydrochloric acid leaching:Sanganisa zvinhu zvakagadziriswa kare nemushonga wehydrochloric acid wakasanganiswa kuti ubvise lycorine. Kushandisa hydrochloric acid kunobatsira kuwedzera kunyungudika kwelycorine, nokudaro zvichivandudza kushanda zvakanaka kwekubvisa.
(4)Kubviswa kwemushonga uchishandisa ultrasonic:Kushandiswa kwetekinoroji yekubvisa zvinhu ne ultrasonic kunogona kukurumidzisa kunyungudika kwe lycorine mumusanganiswa wezvinhu uye kuvandudza kushanda zvakanaka uye kuchena kwekubvisa zvinhu.
(5)Kubviswa kwechloroform:Kubvisa kunoitwa nezvinhu zvinonyungudutsa zvakaita sechloroform, uye lycorine inotamiswa kubva muchikamu chemvura kuenda kuchikamu cheorganic kuti iwedzere kuchenesa chinhu chaunoda.
(6)Kudzoreredza zvinonyungudutsa:Mushure mekubviswa kwechinhu ichi, chinhu ichi chinonyungudika chinotorwa kuburikidza nekubuda kwemvura kana kunyungudika kuti chideredze kushandiswa kwechinhu ichi uye kuvandudza kushandiswa kwechinhu ichi.
(7)Kuchenesa nekuomesa:Kuburikidza nematanho akakodzera ekuchenesa nekuomesa, upfu hwe lycorine hydrochloride yakachena hunowanikwa.
Mukati memaitiro ese ekubvisa, kudzora kusarudzwa kwezvinonyungudutsa, mamiriro ekubvisa (senge pH kukosha, tembiricha, nenguva), uye matanho anotevera ekuchenesa ndiyo kiyi yekuona kuchena kwezvinonyungudutsa uye kuvandudza mwero wekupora. Kushandiswa kwemidziyo yemazuva ano yekubvisa nekuchenesa, senge ultrasonic extractors uye high-performance liquid chromatography (HPLC) systems, kunobatsirawo kuvandudza kushanda zvakanaka kwezvinonyungudutsa uye kunaka kwechigadzirwa.
Kuchengeta: Chengeta munzvimbo inotonhorera, yakaoma, uye yakachena, Dzivirira kubva kuhunyoro nechiedza chakananga.
Pakeji Yakawanda: 25kg/dhiramu.
Nguva Yekutungamira: Mazuva manomwe mushure mekuraira kwako.
Hupenyu hweSherufu: Makore maviri.
Mhinduro: Magadzirirwo akagadzirwa anogonawo kuwanikwa.
Ratidza
Pasi pe100kg, Mazuva 3-5
Basa repasuo nesuo riri nyore kutora zvinhu
Negungwa
Kupfuura 300kg, Mazuva Anosvika 30
Nyanzvi yekubvisa magwaro inodiwa pachiteshi chengarava kuenda kune chimwe chiteshi
Nemhepo
100kg-1000kg, Mazuva mashanu kusvika manomwe
Nyanzvi yekubvisa magwaro kubva kunhandare yendege kuenda kunhandare yendege inodiwa
Bioway Organic yawana zvitupa zveUSDA neEU organic, BRC, ISO, HALAL, KOSHER, uye HACCP.
Lycorine ialkaloid inowanikwa mumiti yakasiyana-siyana, kunyanya mumhuri yeAmaryllidaceae. Heano mimwe miti inozivikanwa ne lycorine:
Lycoris radiata(inozivikanwawo sered spider lily kana manjushage) mushonga wechivanhu wekuChina une lycorine.
Leucojum aestivum(chando chechando chemuzhizha), chinozivikanwawo kuti chine lycorine.
Ungernia sewertzowiichimwe chirimwa chinobva kumhuri yeAmaryllidaceae chakataurwa kuti chine lycorine.
Hippeastrum hybrid (ruva reIsita)uye zvimwe zvirimwa zvine chekuita neAmaryllidaceae zvinozivikanwa kuti zvinobva mu lycorine.
Zvirimwa izvi zvakapararira munzvimbo dzinopisa nedzinopisa pasi rose uye zvine nhoroondo refu yekushandiswa mumishonga yechivanhu. Kuvapo kwe lycorine mumiti iyi kwave kuri nyaya yekutsvagurudza nekuda kwehunhu hwayo hwemishonga, kusanganisira mhedzisiro yayo yakakosha yekurwisa kenza sezvakaratidzwa muzvidzidzo zvakasiyana-siyana.
Lycorine ialkaloid yechisikigo ine mhedzisiro dzakasiyana-siyana dzemishonga, kusanganisira kushandiswa kwayo mukurapa kenza. Kunyange zvazvo yakaratidza mhedzisiro yakanaka muzvidzidzo zvakasiyana-siyana, kune mimwe migumisiro yakashumwa uye zvinofungwa zvine chekuita nekushandiswa kwayo:
Huturu Hwakaderera: Lycorine nemunyu wayo wehydrochloride zvinowanzoratidza huturu hushoma, izvo zvinova chinhu chakanaka pakushandiswa kwekiriniki. Zvakaratidzwa kuti hazvina kuipa zvakanyanya pamasero evanhu akajairwa nembeva dzine hutano, zvichiratidza kuti masero ekenza anosarudza kupfuura mamwe masero akajairwa.
Mhedzisiro Yekubuda Kweropa Kwenguva Pfupi: Kuda kurutsa kwenguva pfupi uye kurutsa zvakaonekwa mushure mekubayiwa lycorine hydrochloride pasi peganda kana neropa, kazhinji zvichidzikira mukati memaawa maviri nehafu pasina kukanganisa kuchengetedzeka kwemakemikari kana ropa.
Hapana Kushanda Kwemuviri Kusina Kushanda: Ongororo dzakaratidza kuti lycorine haikanganisi kushanda kwemuviri mumakonzo, sezvakaedzwa ne rotarod test, zvichiratidza kuti haitungamirire kumigumisiro yepakati petsinga (CNS) ine chekuita nekudzora kushanda kwemuviri.
Kukanganiswa Kwebasa Remota Inofamba Nemhepo: Pamushonga we30 mg/kg, lycorine yakaonekwa ichikanganisa mashandiro emota inofamba-famba nemhepo mumakonzo, sezvinoratidzwa nekudzikira kwemaitiro ekurera uye kuwedzera kwekusagona kufamba.
Maitiro Akajairika uye Kugara Zvakanaka: Dose ye10 mg/kg ye lycorine haina kukanganisa maitiro ese uye kugara zvakanaka kwemakonzo, zvichiratidza kuti iyi inogona kuva dose yakanakisisa yekuongororwa kwekushanda kwekurapa mune ramangwana.
Hapana Migumisiro Yakaipa Kwazvo Pahuremu Hwemuviri Kana Hutano: Kupiwa kwe lycorine ne lycorine hydrochloride hakuna kukonzera migumisiro yakaipa pahuremu hwemuviri kana mamiriro ehutano hwese mumamodheru embeva ane bundu.
Zvakakosha kuziva kuti kunyange hazvo lycorine yakaratidza mukana mukuferefeta kwepamberi pekiriniki, kuongororwa kwenguva refu kwechepfu kuchiri kushaikwa. Tsvagiridzo yakawedzerwa inodiwa kuti unzwisise zvizere kuchengetedzeka kwayo, kunyanya pakushandiswa kwenguva refu uye munzvimbo dzekiriniki. Migumisiro yakaipa uye kuchengetedzeka kwe lycorine zvinogona kusiyana zvichienderana nechiyero, nzira yekushandiswa, uye hunhu hwemurwere wega wega. Gara uchibvunza nyanzvi yehutano usati wafunga nezvekushandisa chero chinowedzera chitsva kana kurapwa.
