Lycorine Hydrochloride
Lycorine hydrochloride ichena kusvika kune-chena poda inobva kune alkaloid lycorine, inowanikwa mumiti yeLycoris radiata (L'Her.), uye ndeyemhuri yeAmaryllidaceae. Lycorine hydrochloride ine zvakasiyana-siyana zvinogona kuitika zvemishonga, kusanganisira anti-tumor, anti-cancer, anti-HCV, anti-inflammatory, anti-bacterial, anti-virus, anti-angiogenesis, uye anti-malaria properties. Inonyungudika mumvura, DMSO, uye ethanol. Chimiro chayo chemakemikari chinoratidzwa neyakaomesesa steroidal framework ine inovava kuravira ine akawanda anoshanda mapoka, anosanganisira hydroxyl uye amino mapoka, achibatsira kune ayo biological zviitiko.
| Product name | Lycorine hydrochloride CAS:2188-68-3 | ||
| Plant Source | Lycoris | ||
| Kuchengetedza mamiriro | Chengetedza nechisimbiso pakupisa kwekamuri | Report date | 2024.08.24 |
| Item | Standard | Mhedzisiro |
| Kuchena(HPLC） | Lycorine hydrochloride≥98% | 99.7% |
| Chitarisiko | Off-white powder | Conforms |
| Chimiro chemuviriics | ||
| Chikamu-saizi | NLT100% 80Mesh | Conforms |
| Kurasikirwa pakuomeswa | ≤1.0% | 1.8% |
| Heavy simbi | ||
| Total metals | ≤10.0ppm | Conforms |
| Tungamira | ≤2.0ppm | Conforms |
| Mercury | ≤1.0ppm | Conforms |
| Cadmium | ≤0.5ppm | Conforms |
| Microorganism | ||
| Huwandu hwemabhakitiriya | ≤1000cfu/g | Conforms |
| Mbiriso | ≤100cfu/g | Conforms |
| Escherichia coli | Haina kubatanidzwa | Haisati yaonekwa |
| Salmonella | Haina kubatanidzwa | Haisati yaonekwa |
| Staphylococcus | Haina kubatanidzwa | Haisati yaonekwa |
| Mhedziso | Qualified | |
Features:
(1) Kuchena Kwepamusoro:Chigadzirwa chedu chinogadziriswa zvine hungwaru kuti ive nehupamhi hwehutsanana, iyo yakakosha pakubudirira kwayo uye kuchengetedzeka mumashandisirwo akasiyana siyana.
(2) Anticancer Properties:Yakaratidza zvakakosha anticancer mhedzisiro inopesana neakasiyana emhando dzegomarara, zvese mu vitro uye mu vivo, kuburikidza nematanho akaita senge innducing cell cycle kusungwa, triggering apoptosis, uye inhibiting angiogenesis.
(3) Chiito Chakawanda:Lycorine hydrochloride inotendwa kuti inodyidzana neakawanda mamorekuru tarisiro, ichipa yakafara-spectrum kushanda kurwisa cancer maseru.
(4) Low Toxicity:Iyo inoratidzira yakaderera chepfu kumasero akajairwa, icho chinhu chakakosha mukugona kwayo kushandiswa semushonga wekurapa.
(5) Pharmacokinetic Profile:Chigadzirwa chacho chakadzidzwa kune yayo pharmacokinetics, ichiratidza kukurumidza kunyura uye nekukurumidza kubviswa kubva muplasma, iyo yakakosha pakuita dosing uye kuronga kurapwa.
(6) Synergistic Migumisiro:Lycorine hydrochloride yakaratidza kukwidziridzwa mhedzisiro kana yakashandiswa pamwe chete nemimwe mishonga, iyo inogona kubatsira mukukunda kurwisa zvinodhaka nekuvandudza mhedzisiro yekurapa.
(7) Tsvakurudzo-inotsigirwa:Chigadzirwa chacho chinotsigirwa nekutsvakurudza kwakawanda, kupa hwaro hwakasimba hwekushandiswa kwayo mukugadzirwa kwemishonga uye kushandiswa kwekliniki.
(8) Kuvimbisa Hunhu:Yakaomesesa yemhando yekudzora matanho ari munzvimbo yese yekugadzira maitiro kuti ave nechokwadi chekuenderana uye kuvimbika kwechigadzirwa.
(9) Zvishandiso Zvakasiyana-siyana:Inokodzera kushandiswa mukutsvagisa uye kusimudzira kwemishonga yekushandisa, kusanganisira kuwanikwa kwezvinodhaka uye kukura kwekurapa cancer.
(10) Kutevedza:Yakagadzirwa ichitevera GMP zviyero kuti ive nechokwadi chekuchengetedza uye kushanda kwechigadzirwa.
(1) Indasitiri yemishonga:Lycorine hydrochloride inoshandiswa mukugadzira antiviral uye anticancer mishonga.
(2) Indasitiri yeBiotechnology:Inoshandiswa mukutsvagisa nekuvandudza kwevatsva vekurapa vamiririri uye kugadzirwa kwezvinodhaka.
(3) Tsvakurudzo yechigadzirwa chechisikigo:Lycorine hydrochloride inodzidzwa kune yayo inogona kubatsira hutano uye mishonga yemishonga.
(4) Indasitiri yemakemikari:Inogona kushandiswa sekemikari yepakati mukubatanidzwa kwemamwe macomputer.
(5) Indasitiri yezvekurima:Lycorine hydrochloride yakaferefetwa nekuda kwekugona kwayo semushonga wezvipembenene wemusikirwo uye mutongi wekukura kwechirimwa.
Iyo yekubvisa maitiro e lycorine hydrochloride inowanzo sanganisira anotevera matanho akakosha ekuona kuchena kweiyo solvent uye kuvandudza mwero wekudzoreredza:
(1) Kusarudzwa kwezvinhu zvakasvibirira uye pretreatment:Sarudza akakodzera Amaryllidaceae chirimwa mbishi zvinhu, zvakaita seAmaryllis bulbs, wogeza, woomesa uye uzvipwanye kuti uve nechokwadi chekuchena kwezvinhu uye uise hwaro hwekuzochera kunotevera.
(2)Composite enzyme pretreatment:Shandisa ma enzymes akaomesesa (akadai se cellulase uye pectinase) pretreat yakapwanyika mbishi kuodza chirimwa maseru madziro uye kunatsiridza kunotevera kudhirowa kushanda zvakanaka.
(3)Dilute hydrochloric acid leaching:Sanganisa pretreated raw materials ne dilute hydrochloric acid solution kuti ubvise lycorine. Kushandiswa kwehydrochloric acid kunobatsira kuwedzera kunyungudika kwe lycorine, nekudaro kunatsiridza kudhirowa kwekuita.
(4)Ultrasonic-yakabatsirwa kubviswa:Iko kushandiswa kweiyo ultrasonic-yakabatsira yekubvisa tekinoroji inogona kukurumidza kunyungudika maitiro e lycorine mune solvent uye kunatsiridza kudhirowa kwekuita uye kuchena.
(5)Kubviswa kweChloroform:Kubvisa kunoitwa ne organic solvents senge chloroform, uye iyo lycorine inotamiswa kubva pachikamu chemvura ichienda kune iyo organic chikamu kuti ienderere mberi kuchenesa iyo inotarirwa komisheni.
(6)Solvent recovery:Mushure mekuita kwekubvisa, iyo solvent inodzoserwa kuburikidza ne evaporation kana distillation kuderedza kunyungudutsa kushandiswa uye kugadzirisa hupfumi.
(7)Kuchenesa uye kuomesa:Kuburikidza nekucheneswa kwakakodzera uye matanho ekuomesa, yakachena lycorine hydrochloride poda inowanikwa.
Mukati mese muitiro wekubvisa, kudzora kusarudzwa kwekunyungudutsa, mamiriro ekubvisa (akadai pH kukosha, tembiricha, uye nguva), uye anotevera ekucheneswa matanho ndiyo kiyi yekuvimbisa kuchena kwekunyungudika nekuvandudza mwero wekudzoreredza. Kushandiswa kwemazuva ano ekuchera uye kuchenesa michina, yakadai se ultrasonic extractors uye yakakwirira-performance liquid chromatography (HPLC) masisitimu, inobatsirawo kuvandudza kudhirowa kwekuita uye kunaka kwechigadzirwa.
Kuchengeta: Ramba uri munzvimbo inotonhorera, yakaoma, uye yakachena, Dzivirira kubva pakunyorova uye kuchiedza chakananga.
Yakawanda Package: 25kg / chigubhu.
Nguva Yekutungamira: Mazuva 7 mushure mekuraira kwako.
Sherufu Hupenyu: 2 makore.
Chengetedza: Madimikira akajairwa zvakare anogona kuwanikwa.
Express
Pasi pe100kg, 3-5Days
Door to door service iri nyore kutora zvinhu
NeGungwa
Over300kg, Around 30 Mazuva
Port kuenda kuchiteshi chebasa inyanzvi clearance broker inodiwa
By Air
100kg-1000kg, 5-7Days
Airport kuenda kuairport service professional clearance broker inodiwa
Bioway Organic yakawana USDA uye EU organic, BRC, ISO, HALAL, KOSHER, uye HACCP zvitupa.
Lycorine ndeye alkaloid inowanzoitika inogona kuwanikwa mumiti yakati wandei, kunyanya mukati memhuri yeAmaryllidaceae. Heano mimwe miti inozivikanwa kuti ine lycorine:
Lycoris radiata(inozivikanwawo sered spider lily kana manjushage) mushonga wechiChinese wekuChina une lycorine.
Leucojum aestivum(chando chechando chezhizha), inozivikanwawo kuve ine lycorine.
Ungernia sewertzowiichimwe chirimwa kubva kumhuri yeAmaryllidaceae inonzi ine lycorine.
Hippeastrum hybrid (iyo Easter lily)uye zvimwe zvine chekuita neAmaryllidaceae zvirimwa zvinozivikanwa zvitubu zve lycorine.
Izvi zvinomera zvakaparadzirwa zvakanyanya munzvimbo dzinopisa uye dzinopisa pasi rose uye dzine nhoroondo refu yekushandiswa mumishonga yechivanhu. Kuvapo kwe lycorine mumiti iyi yanga iri nyaya yekutsvagisa nekuda kwekugona kwayo kwemishonga yemishonga, kusanganisira yayo yakakosha anticancer mhedzisiro sezvakaratidzwa muzvidzidzo zvakasiyana.
Lycorine ndeye alkaloid yechisikigo ine huwandu hwakawanda hwemishonga yemishonga, kusanganisira iyo inogona kushandiswa mukurapa cancer. Kunyange yakaratidza mhedzisiro inovimbisa muzvidzidzo zvakasiyana, kune mamwe akashumwa mhedzisiro uye kufunga kwakabatana nekushandiswa kwayo:
Yakaderera Toxicity: Lycorine uye yayo hydrochloride munyu kazhinji inoratidza yakaderera muchetura, inova hunhu hwakanaka kune kiriniki application. Izvo zvakaratidzwa kuve nekushomeka kwakashata mhedzisiro pamasero emunhu akajairwa uye mbeva dzine hutano, zvichikurudzira imwe nhanho yekusarudza kwekenza maseru pamusoro peakajairwa tishu.
Transient Emetic Effects: Kusvotesa kwenguva pfupi uye kurutsa zvakaonekwa zvichitevera jekiseni rezasi kana remutsinga relycorine hydrochloride, rinowanzopera mukati meawa 2.5 pasina kukanganisa biochemical kana hematological kuchengetedza.
Kwete Kukanganiswa Kwemotokari Kubatanidza: Zvidzidzo zvakaratidza kuti serial doses ye lycorine haibatsiri kuwirirana kwemotokari mumakonzo, sezvakaedzwa nerotarod test, zvichiratidza kuti haitungamiri kune central central nervous system (CNS) migumisiro yemigumisiro ine chokuita nekutonga motokari.
Impact on Spontaneous Locomotor Activity: Pachiyero che 30 mg / kg, lycorine yakaonekwa kuti inokanganisa maitiro ezvigadziro emakonzo mumakonzo, sezvinoratidzwa nekuderera kwemaitiro ekurera uye kuwedzera kwekusafamba.
General Behavior uye Well-being: Chiyero che 10 mg / kg ye lycorine haina kukanganisa maitiro akazara uye kugara zvakanaka kwemakonzo, zvichiratidza kuti iyi inogona kunge iri muyero wakakwana weramangwana rekurapa efficacy assessment.
Hapana Zvakaipa Zvakaipa Zvakaipa Pahuremu hweMuviri kana Hutano Mamiriro: Kudzora lycorine uye lycorine hydrochloride hakuna kukonzera zvinoonekwa mhedzisiro pahuremu hwemuviri kana hutano hwese hutano mumamodhi anotakura tumor.
Zvakakosha kucherechedza kuti nepo lycorine yakaratidza kugona mukuferefeta kwepamberi, kuongororwa kwehupfu kwenguva refu kuchiri kushaikwa. Kumwe kutsvagisa kunodiwa kuti unzwisise zvizere chimiro chayo chekuchengetedza, kunyanya kushandiswa kwenguva refu uye mumakiriniki. Iyo mhedzisiro uye kuchengetedzwa kwe lycorine inogona kusiyana zvichienderana nedosi, nzira yekutonga, uye hunhu hwemurwere. Gara uchibvunzurudza nenyanzvi yezvehutano usati wafunga nezvekushandisa chero chitsva chekuwedzera kana kurapwa.
